Fish Oil Research

NEW! DHA 600 Omega-3 Pills

written by Vin Kutty

comments 73 comments

Prenatal supplement…or brain health supplement?*


OmegaVia DHA supplement
The new OmegaVia DHA 600 has, well, 600 mg of DHA per pill. It’s the only
product that provides enough DHA for the second half of pregnancy.

OmegaVia DHA 600 is our newest product.

You kept bugging us. Now here it is.

What is it?

  • It’s an ultra-pure DHA-only supplement made from Anchovy, Sardine, and Mackerel
  • Each capsule has 600 mg of DHA Omega-3
  • The DHA is in the well-absorbed triglyceride (rTG) form

Who should take it:

  • Men and women considering parenthood ( 4 months before conception)*
  • Pregnant and nursing women (600 to 900 mg DHA per day)*
  • Adults concerned about brain health*
  • Adults concerned about eye health*

How much does it cost?

$25.99 for 120 softgels

Why it’s special:

  • It has the most DHA available in one pill. (Yet it’s not a horse pill)
  • It’s made using a new gentle, heat-free technology called enzymatic concentration. Less heat equals less damage to delicate Omega-3 molecules.


  • Purified to remove mercury
  • The Omega-3 is in the well-absorbed triglyceride form
  • It’s enteric coated to reduce odor and burping
  • It is third-party tested for your peace of mind
DHA supplement pill size comparison
DHA 600 is larger than EPA 500 pills but much smaller than regular OmegaVia


What’s the right DHA dosage for brain health?

There is always some news report about why fish oil doesn’t work.

Recently, there was a lot of media attention about one study that used 320 mg of DHA per day. The media reported that it does nothing for brain health or eyes. A ‘waste of money,’ said Newsweek.

Case closed. Toss your fish oil pills.

Not so fast.

While we were developing this formula, I spent a lot of time reviewing DHA studies (certainly more time than Jessica Firger from Newsweek) from the last decade that focused on cognitive health.

I noticed a couple of things:

  1. Studies that used less than 500 mg per day consistently failed to provide cognitive benefits.*
  2. Studies that used more than 600 mg or so showed fairly consistent benefits.*

600 to 700 mg of DHA per day seemed to be the sweet spot – the least amount of DHA that could be expected to provide benefits. It seems fair to say that if you take two pills (1200 mg DHA per day) that you’d tilt the odds in your favor.

This is the reason why our formula is ‘DHA 600’ and not ‘DHA 500.’ DHA 700 would have been better but we wanted to keep cost and pill size approachable.

This data was brilliantly reported by Adam Ismail of GOED as a response to mass media trashing DHA.

In the chart below, I have shamelessly combined my data with Adam’s eye-opening chart. (Yes, there are a couple of studies that used > 500 mg DHA that failed to provide benefits and if I keep looking, I’ll probably find a study or two that shows benefits at sub-500 mg dosage. That’s how science works.)

DHA & Brain Health Clinical Studies:
Dosage and Results

DHA dosage and cognitive benefits
Comparison of recent DHA research: studies that used less than 500 mg of DHA per day showed a near unanimous lack of cognitive or brain health benefit.


Dosage matters.

As Dr. Barry Sears regularly explains to his readers, if you take a placebo dose, you can expect a placebo result.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


  1. Hi,I currently the omegavia 780 epa 260 dha.In some of my reading I have seen products recomending higher levels of dha. I am wondering what your current thoughts are on this subject and could you comment on the trade marked product vesisorb.

    • Hi Don – think of EPA and DHA has your right hand and left. Ideally, you need both. They have different roles in the body. DHA tends to be used for structural functions like building stuff. Think bricks of a building. EPA is the water and electricity flowing thru the building. EPA plays a more functional role, not a structural one.

      EPA supports healthy inflammation response, and also support mood health and healthy triglyceride levels when used as part of healthy diet and exercise plan. DHA supports brain and eye health. It is critical during pregnancy and breast feeding due to its importance in brain development.

      OmegaVia (the original one) was designed to have a little more EPA than DHA to support healthy inflammation response. However, there is enough DHA there still to meet your daily needs. The new DHA product (above) is for those focused on pregnancy, brain and eye health.

      *Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

        • Hi Ken – I only watched about 5 minutes of it. That’s all I could take. In my opinion, this video is misleading. There are bits and pieces of science and facts throughout the video, but it’s mostly self-serving. I’d urge anyone to be cautious of any video that starts with ‘what they don’t want you to know’ because it suggests a conspiracy. Virtually all information on fish oil is available either freely or for purchase in the case of some journal articles. So there is hardly anything that is unavailable.

          No one disagrees on the following:
          1) It’s best to get all your nutrients from food, including Omega-3s. Fish oil Supplements are for times when you don’t eat enough fish.
          2) Too much fish oil (greater than 5 grams Omegas per day) taken for years on end may backfire due to oxidative load that much polyunsaturated fats place on the body.

          Taking 1 to 2 grams of Omegas daily is fine. No one has shown harm in taking that much.

          Are fish oils adulterated? I don’t think so. Virtually all fish oils contain the Omegas they promise on the label (in the US anyway) but some of them have high oxidation byproducts, which means some may be slightly rancid. This is where third-party test sites like IFOS, ConsumerLab, or LabDoor come in. You buy products that are shown to be fresh and not rancid. Simple.

  2. Hi,

    I am not sure which Omegavia product I should buy. I bought the OmegaVia EPA 500. EPA Omega-3. Triglyceride-form EPA-only formula, 120 Capsules. 500 mg EPA per pill on Amazon

    And then I tried the OmegaVia Omega-3, Enteric Odorless/Burp-Free. 1105 mg Omega-3 – Highest Omega-3 per pill.

    The first one helped my mood. I was able to concentrate better.
    The second one was great for my skin and reduced my challenges with inflammation considerably. It has also assisted my recall but not my
    concentration. Not sure why that is.

    These are my challenges: inflammation, and brain health, mood, skin. I was a battered child and teen and suffered several blows to head, ages 6-19. I have been taking the fish oil along with my green foods, (spirulina, barley grass juice powder, e3live, and wheat grass juice powder). The fish oil helps me remember numbers well this is a big deal for me because I have not been able to recall numbers this well since I was thrown against a wall at the age of 8. So, I am very excited about what it is doing for my brain.

    The Omegavia is the best fish oil product I’ve come across.

    Do I need to purchase two different ones? I am running low on the product.

    Lastly, I have also started taking Viobin Wheat Germ oil. I take one teaspoon each day. Is it okay to take Wheat Germ oil even though i am taking the fish oil? I don’t mind alternating. It has been a great help. Thank you.

    • Hi WM – your post made me go quiet for a while.

      Since you want to focus on a lot of different areas, I think the original OmegaVia with 1105 mg of Omega-3 per pill will do. You don’t need to buy two separate products. I am not a big fan of greens – you’ll do better with increasing the quantity and variety of vegetables and tubers in your diet. Certainly not a big fan of wheat germ oil or anything that comes from wheat.

      Take care of yourself. Since others didn’t.

  3. Hi vin, i am currently taking blue ocean professional omega 3 2100 mg for the last one month. They didn’t mention their source of oil on label and when i inquired from them they said their source would be either Peruvian Anchovies or Alaskan Pollock. Is it good source or not, and when can we get your products in india? Am i taking right product for anti-inflamatory purpose.

    • Hi Babli – Blue Ocean is generally a good product. But one of their products failed a recent test. It had a little less Omega-3 than claimed on the label. But the product quality is otherwise very good from my experience. If you take 2000-3000 mg of Omega-3 per day as part of a healthy diet and exercise plan, you should notice an overall healthy inflammation response.*

      *Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

  4. Hi Vin!
    I am loving Omegavia so far. I have been aware of the benefits of DHA during pregnancy throughout my pregnancy and was taking a highly recommended Fish Oil that had much higher EPA than DHA. It wasn’t until my 6th or 7th month that I found your product and began taking it and have gathered a lot more information about EPA and DHA.

    Will the benefits be lessened because I have been taking much more EPA than DHA throughout this pregnancy? And could there be negative effects?
    Should my intake of DHA be balanced by an intake of EPA? Is there a ratio amount?
    (I am currently taking the 600 capsule twice a day along with an EPA/DHA capsule EPA 625/ DHA 244.)

  5. Is there a health reason to prefer this DHA 600 to the Ovega-3 vegan DHA?

    I currently take two EPA 500 and one regular omegavia per day to help with mood. I’m thinking about pregancy and the regimen I was thinking of was 2 regular Omegavias and 2 of the vegan ovega-3 per day. Is there a reason to think that -from a nutrition perspective, not pill quantity or cost-your DHA 600 would be better than taking 2 ovega-3 pills?

    • Hi EastCoaster – no. There is no health or nutrition reason to choose Ovega-3 over this item. If you are vegan, then, yes, Ovega-3 is the obvious choice.

  6. I tried to post this earlier.

    Right now I take 2 500 EPAs and 1 regular omegavia per day (mostly for mood). I’ve been thinking about pregnancy and wondering about taking 2 regular omegavias and 2 of the ovega-3 vegan dha.

    Right now I’m getting 1780 mg EPA (500×2 + 780) and 260mg DHA plus 65m other omega 3.

    Under the proposed regimen I would get:

    EPA (780×2 + 135×2) DHA (260×2 + 270×2)

    EPA 1830mg DHA 1060mg DHA

    Is there any nutritional reason why it would be better to get the dha from fish than from the algal oil?


    • Hi EastCoaster – I answered your earlier question yesterday…may be you’re not seeing it for some reason.

      There is no nutritional reason to choose fish over algae. Or vice versa. If you get the DHA into your body, your body will thank you, regardless of source. Some algae extracted DHA products may have some remaining solvents like hexane, acetone, or isopropanol. I have no idea if that is the case with your algae DHA.

      • Thanks for the response. There was a delay in the post showing up, so I thought my comment hadn’t posted.

        I was also asking about the best way to go about making sure that I get adequate EPA for myself even when upping DHA.

        • Hi EastCoaster – I think one regular OmegaVia and one DHA 600 should be plenty. As you get closer to 2nd and 3rd trimesters of pregnancy, you can always increase either pill by one.

  7. You have mentioned before in one of your articles about unopposed EPA being effective when one is interested in getting its benefits. Does the same work for DHA? Should I avoid a product that has EPA if I am more interested in the DHA component?

    • Hi NG – no need to avoid either. That would be a bad idea. For mood support, the evidence shows that more EPA than DHA helps. No such evidence exists for any other health condition.*

  8. Hey there Mr Kutty,

    My plan to improve my health, the dietary portion of it, is temporarily face down in the water. I have read numerous links lately regarding statins: specifically, statins and fish oil, as well as other related pharmacological and supplemental studies including coq10, K2 and vitamin E, etc. I thought, “Alright, finally! There it is in black and white–proof that it works–empirical results.”

    However, I went on to read anther link, “Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms”. That was a veritable horror show about the apparent Ted Bundy of prescription medications. Who knew? Before you correctly suggest I see my Doctor, keep in mind that she prescribed them. On one hand, they are touted as miracles, on the other hand, not so much. Kind of like the wheat/whole grains issue—ground zero of healthy food… that is going to kill you. Have you any advice? These conundrums are frustrating. Thanks

  9. Hi Dennis – I’d go with the regular OmegaVia for now. It is the best way to get a high amount of Omega-3 into your body with one pill. I’d take 2-3 per day.

  10. Hello, Thank you for your putting so much information out there! I truly enjoy your articles and I can’t tell you how much I appreciate them! I’ve been reading your articles for a while. I am currently a little over 5 months pregnant with my first and it’s GIRL :).

    I’ve been taking the following:
    4 Nordic Naturals Prenatal (serving size: 2)- 480 DHA & 205 EPA
    1 Carlson super DHA 500
    Total: 1460 DHA and 410 EPA

    I didn’t realize that EPA was as important as DHA and I am concerned about it. From your experience with your wife, what would you recommend that I take for my last trimester. I am thinking about ordering the Omegavia regular and the Omegavia DHA 600. How many should I take Starting my 6th month and is ordering from Amazon the same as ordering directly on your website? Lastly, what magnesium pills do you recommend and how much mg should I be getting?

    Thank you in advance for your assistance.

    • Hi Aida – congratulations! And glad you find the articles here useful. I think your total DHA is fine for the whole pregnancy. EPA is OK too, but could be higher.

      You could keep your routine the same or you could use OmegaVia (regular) and OmegaVia DHA 600 in combo. One regular and 1 or 2 DHA per day.

      Buying from this site or Amazon is the same. Except I don’t think Amazon offers ‘Auto-ship’ and the discount that goes with it. As for Magnesium, try the one from our sister company, InnovixLabs on Amazon. Aim for 400 mg Magnesium per day, but check with your OB before you add anything new to your routine. Good luck with the pregnancy.

  11. Hi Vin,

    I read somewhere that your body becomes saturated with DHA at a dose of about 900 mg/day, so taking more than that won’t do any good. Is that true?

    • Hi Peter – I dont know how that could be true. It is possible that there is no need for more than 900 mg DHA per day, but it can always be converted to EPA if there is excess.

    • Hi Peter – DHA is a longer molecule than EPA. By 2 carbons. Generally, elongation of any molecule is more cumbersome and consumes energy, so the body isn’t very efficient at it. So conversion of EPA to DHA is not as efficient as the reverse. The answer to your question: yes, EPA can be converted. But DHA to EPA works much easier and faster.

  12. Hey Vin,

    (This unrelated to DHA but this was the most recent article)

    I have been following your health recommendations and would like to get your take on some things.

    I am thinking about incorporating fish into my diet certain weeks so as not to have to supplement ALL the time with EPA pills. Does mercury toxicity concern you? (I heard Salmon was good on this front)

    Per your recommendation I have been eating a lot of eggs (6 whites, 2 yolks a day) but I recently came across research connecting eggs to Prostate Cancer and its progression. Have you heard about this?

    Lastly, I recently read a few articles warning against olive and coconut oil (especially coconut). Is this just another case of people fearing any and all fat?

    • HI Sullivan – wild salmon is an excellent food. Mercury is not high in salmon.

      There has never, ever been cause and effect shown between eating eggs and cancer of any sort. I feel pretty comfortable is saying virtually everyone who has cancer has eaten eggs at some point. So it is easy to connect the two. Otherwise, I think it is hogwash. I feel the same way about the olive/coconut oil article.

  13. Hi Vin,

    What percentage of DHA is present in the sn-2 position of this product?
    And maybe, if you have the time, could you elaborate on the importance (or not) of this in your opinion?


    • Hi Nik – as far as we know (based on NMR analysis), the DHA is equally distributed between sn-1, 2, and 3 positions on the glycerol backbone. In other words, about a third of it is probably in the sn-2 position.

      Just curious – why do you ask?

      • I’ve been following Jack Kruse for some time. He says that DHA has to be in the SN-2 position to get into the brain and nervous system.

        Rhonda Patrick seems to favor Krill for DHA and fish oil (she apparently uses Nordic Naturals Extra EPA) for EPA. Maybe you should sponsor her with some OmegaVia EPA? 😉 Anyway, seems like a decent approach? Given Krill is too expensive to cover all to make sense.

        Feel free to cut out parts of the text if you wish. I just appreciate your opinion since I like your writings and view on things.

  14. Hi Vin,
    I have 2 boys – a 10yr old, who has concentration issues and a 4.5 yr old with sensory issues. Their diet is full of sugar juice and artificial stuff, while I am tackling that, please advise what Omega-3 to give them ? And how much.

  15. Hello Vin,

    Earlier I used to take Nordic Naturals EPA Xtra, but I recently started using “Omegavia Fish Oil” supplement after Omegavia switched to the rTG form.
    Now, the supplement is Enteric-Coated, which means it won’t be digested in the stomach, and if I want to avoid this is it OK if I chew on the softgel? Once I feel that all the oil has been taken in, I spit out the capsule body. I have done it a couple of times and the oil tastes fine (this really shows it’s good quality stuff, so kudos to you guys!!!), can you please tell me if this method is OK and doesn’t affect the absorption in a negative way.

    • Hi Pankaj – I would not recommend chewing the capsule to release the oil in the mouth. There is no biological or scientific need to. There is almost no gastric digestion of Omega-3 in the stomach. Virtually all Omega-3 digestion happens in the intestines. So why go through the hassle? The only people up in arms about enteric coating are companies selling non-enteric-coated fish oil.

  16. Hi Vin,

    I have been diagnosed with postural orthostatic tachycardia syndrome (POTS). My doctor says that I should consume Omega-3. I know that a high EPA, lower DHA formula is beneficial for most people, but in my case would you recommend a higher amount of DHA for such a neurological condition? Right now I am consuming 1.5 grams, mostly EPA because anxiety/depression are some of my symptoms. But I am thinking now I may need to adjust it because of my recent diagnose. I have also heard Choline supplementation is beneficial for POTS. What are your thoughts? Thank you.

    • Hi Joe – I am not aware of any Omega-3 research that’s been applied directly at mitigating POTS. If your doctor wants you to take Omega-3 and you want to focus on nervous health, then a little DHA, like this DHA 600 may help. Frankly, I don’t know whether it will or not. However, here is something to keep in mind: even though there appears to be a strong genetic component here, POTS is often seen with other ‘lifestyle’ diseases like chronic fatigue, diabetes, and IBS, most of which can be somewhat managed with strict control over diet and lifestyle that reduce inflammation and enhance gut health/microbiome. Something to think about in addition to adding DHA to your EPA routine.

    • Hi JW – it’s basic high-vacuum distillation. The two molecules, EPA and DHA, have different molecular weight and boiling points. They are easily separated.

  17. In another article on this website: it says that the brain only takes in 4 mg of DHA per day, and that the half life is around 2.5 years. I thought that this meant higher dosed DHA is not necessary for maximal brain utilization daily?

    The article says that the heart, eyes, and other cells also use DHA, but it seemed the “gist” was that higher DHA isn’t necessary and it could inhibit DGLA production since DHA competes with GLA for an enzyme called delta-6-desaturase which means less GLA production.

    Could you clarify more into what an optimal dosage of DHA would be for someone interested in brain performance. I wonder if the 4 mg rate limit be increased?

    • Hi Eli – that article was written with a narrow focus and with data that now feels irrelevant. I still think the 4 mg per day number is still correct, but it does not take into consideration other benefits or mechanisms of action of DHA. There appear to be unique benefits to both EPA and DHA. Example: more EPA helps with mood while more DHA helps with heart rate moderation and cognitive health. Also, it is clear that cognitive health benefits of DHA starts at around 600-800 mg of DHA per day, which is FAR higher than 4 mg. So, if you want brain performance, I’d target 600-800 mg DHA per day along with elimination of sugar, processed foods, daily exercise, plenty of prebiotic fiber, healthy sleep habits etc.

      • Thank you for the reply, I appreciate it!
        Last question I promise –

        Does EPA compete with DHA in any way when trying to cross the blood brain barrier or in the brain itself during membrane integration?

        I only ask because I see a lot of fish oils on the market with much higher EPA and although it is still easy to reach 600 – 800 mg DHA with those ratios, I wonder if much higher levels of EPA going along with it might compete/block DHA in some way.

        • Hi Eli – there is virtually no EPA in the brain. But EPA, DPA, and DHA can and do cross the blood brain barrier. But the structural Omega-3 in the brain is DHA and its incorporation into the brain is unimpeded by EPA or DPA. In other words, if you take a product with high levels of EPA (like OmegaVia), the DHA present will still be properly used by the body. It is for those seeking specific ratios that we introduced this DHA item and the EPA 500.

      • Hi,

        First of all, thanks for all the articles and replies to questions on them. All the information has been great.

        Regarding the older article (, are you able to go back and add a note at the top to see the new info in this one?

        I’m asking because the other article is still a high Google result, so I landed on it from there and didn’t see this post until browsing the site much later.


  18. I found your website two years ago, when i had chronic knee pain due to a bike accident. We exchanged some messages, and i followed your advice and took 1200 EPA/day and while it didnt completely erase my pain, it reduced my pain/inflammation significantly. It was a life saver seriously.

    I learnt a lot from your advices in the comment sections, and im really thankful of this. Since that time Im telling people who has pain to try/come here to learn with omegavia and/or about high quality fish oil.

    Now I just came back again to your site to ask your advice. I just learnt recently i have/had a chronic inflammation in one of my teeth roots, and dentists were telling me it may affect all my recovery/physio/knee pain as well. So last week I had a tooth extraction, and since that time i have pain/inflammation in my mouth now. The dentists told me to take antibiotic, but if there is any way im trying to avoid antibiotics. (I have some digestion issues: too much intestinal gas and eructation and Im trying to save my stomach from further troubles) So, now im suffering (no painkillers) and looking for urgent alternative ways to reduce inflammation/pain and help my body to recover.

    Do you think higher intake of EPA daily can help in this issue? Im planning 1000-1300 mg EPA first, if there is no effect up to 2000mg EPA/day for a 10 days period of time.

    Do you may have any other advice which could help? If you say, follow the dentist order and there is no other way then take antibiotic i will accept it.

    Thanks for your advice, and sorry for my english mistakes,


    • Hi Robbie – I’m glad EPA helped with the knee issues. However, EPA will not replace the need for antibiotics or painkillers after tooth extraction. Antibiotics are a necessary evil and if you need it, you need to take it. For the immediate future, following your doctor’s advice is critical.

      Beyond that, if you want to maintain good dental health, start with elimination of all sweet beverages, sugar and refined grains. Floss your teeth at least once a day. And take Vitamin K2 to strengthen your teeth. Our sister company makes a good K2:

      • Thank you for your quick reply! Ok, I will wait one more day, and if its not going to get better, i will choose antibiotics.. (Im doing this in the last 6 days, waiting for some miracle to happen, but nothing happened yet just the pain stayed..) Do you may have any research/learning materials about the health benefits of K2 ? I never heard of K2 before, and tonight im going to examine this topic. Do you may know any natural food supplement as teeth pain killer?

        Thanks for your quick response, please let me know if you anytime end up in Budapest:)


  19. I was going through your site and I understand you are an authority on subject of Omega 3s. Compliment you for the wealth of information shared on on the website.

    I am writing to you with a very specific query and hope you will be able to help me.

    I am Male, 41 years.
    Have high triglycerides (300 – 340 mg/dL) since I was 25 years & this is heriditary (runs in family with mother and younger brother also has high triglycerides).
    I also suffer from depression, which could be part attributed to fact that I am Beta Thal minor and as such my Hb levels are 11-12.

    For Triglycerides I inititally tried EPA+ DHA but it made me sleepy, drowsy, confused, lethargic & sloppy.
    Have tried multiple formulations of EPA and they all make me worse with above mentioned symptoms and makes my depression worse.
    Is this a known side effect of EPA? I read somewhere that EPA reduces cortisol in the body and dont know if that is a plausible explanation. Is it correct that EPA reduces cortisol?
    Though your website mentions EPA as main product for TGL reduction but I am apprehensive of using it owing to existing high TGL levels.

    I have tried DHA in past and it has yielded good results especially on mental performance. Have now got a bottle of Omegavia DHA 600.
    Had questions with respect to Omegavia DHA 600:
    1. Understand DHA in OmegaVia 600 is in Triglyceride form.
    Given my existing condition of High triglycerides, would OmegaVia 600 help in decreasing TGL levels or TGL form of DHA may actually elevate existing TGL levels?
    2. If yes to above question, what should be dosage & duration of DHA to see results.
    3. Can DHA also help with depression? My depression is more due to dopamine deficiency/neurotransmission.
    4. Does DHA affect cortisol levels as well ?

    I eagerly look forward to hearing your comments.
    Also, please do let me know any suggestions or advice you may like to give based on my condition and how Omega 3s could help me.



    • Hi Ron – EPA and DHA are not known to cause sleepiness or confusion. Neither are these two Omega-3s known to worsen depression.

      As for cortisol, topical application of cortisol temporarily weakens the effect of Omega-3.

      EPA alone is not suggested for triglyceride reduction. We recommend a combination of three things:
      1. A diet that is very low in sugar, grains, and refined carbohydrates. In other words, mostly vegetables, and some protein, with generous amounts of healthy fats.
      2. An exercise plan that includes both resistance and aerobic exercises
      3. 3000 mg of Omega-3 per day (both EPA and DHA)

      The DHA in DHA 600 will not elevate triglyceride because of the triglyceride form DHA – those are two different things.

      EPA seems to help with mood more than DHA.

    • Hi Kal – there are many reasons why studies do or do not show benefits. This applies to all nutrition science, not just Omega-3.

      I’m attaching our standard response regarding this study.

      First, there were two studies published at the same time. One was mildly positive and the other was ‘null’ or no benefit. The positive study was completely ignored by the media.

      1) There are decades of research showing a cardioprotective effect of omega-3s. This includes meta-analyses, RCTs, epidemiological studies, animal studies and in vitro studies.

      2) While Dr. Lee Hooper, the project lead for this systematic review, says she is “… confident in the findings of this review which go against the popular belief that long-chain omega-3 supplements protect the heart,” her analysis focuses on only part of the existing evidence and even there contradicts previous meta-analyses that focused more carefully on some of the most relevant outcomes (cardiac death, blood pressure, triglycerides). What she gained in comprehensiveness, she lost in depth.

      3) Perhaps the biggest shortcoming of the CHD meta-analysis is that it is underpowered. Most readers of this article will assume that if there is a true effect on CHD mortality, for example, then this study would have a good chance of detecting it. In fact, that is not the case – a real effect of this size would be unlikely to be detected unless the number of participants were doubled. This stresses the importance of considering all existing science, not just RCTs.

      The way the authors define cardiovascular mortality is non-standard, and using this definition reduced the number of events considered, as compared to other published meta-analyses. This choice artificially reduced the chances of an already underpowered analysis to detect a significant effect.

      And finally, here is a related piece I wrote back in 2014:

  20. what do you think about the claims of Scott Doughman, Ph.D, owner of Source-Omega International? He claims that all the efa’s the human body needs is DHA and only minuscule amounts of EPA, whether from algae sources or fish oil. He further claims that regardless of the starting epa/dha ratio, the liver reprocesses the fatty acids in a few hours resulting in an avg 85% dha/5% epa. He says these ratios are what the human body inherently needs and that even though the liver is very efficient at retroconverting the efas it is easier on the body to take what it naturally needs to begin with. He says the most important thing is to take enough efa’s, 700-1400mg, regardless of the specific ratios.

    • Hi Joseph – I could say a lot, but I won’t. It is rare for me to pass on stuff like this. Instead of saying nothing, I’ll say this: I somewhat disagree. 🙂

    • I am bulking to put on muscle at the gym, therefore I need a lot of protein. I have cut down on as many omega 6 rich foods as I can, and take 1100mg of both dha and epa combined per day. I also eat a handful of chia seeds per day, and fish at least a few times a week. I eat 2 chicken breasts and a handful of nuts per day, as well as a couple tablespoons of extra virgin olive oil. Do you think this is a healthy balance, and would you advise against eating eggs daily on top of this (which I am considering doing)?

      • Hi Jack – based on what you’ve shared, this is not an unusual diet to put on muscle mass. Having said that, putting on muscle and health are occasionally at odds. We say this because excess protein accelerates aging. Your Omega and fish consumption looks OK. However, if you’re trying to reduce inflammation, I’d cut back on seeds and nuts…and focus on leafy green, roots, berries. Extra virgin olive oil is great.

        We never suggest avoiding eggs.

        • Thanks, that was a very helpful comprehensive answer! A further question..

          What is your opinion on cooking oils? As i’ve already stated I use extra virgin olive oil, but i’m considering using cold pressed rapeseed, and virgin coconut oil too. How will this affect the omega balance in my diet in your opinion?

          • Hi Jack – I am not a fan of Canola (rapeseed) oil because it is high in Omega-6. It will hurt your Omega-3 to 6 ratio. Coconut oil is Ok for some. Others find that it increases their LDL a little. My issue with coconut oil is that unless I use deodorized forms, its flavor overpowers everything. These days, I use some butter but mostly stick with extra virgin olive oil for salads and extra light olive oil for high heat cooking.

            • Hi Vin. Is it possible that fish oil can make insomnia worse if taken too late in the day? I know it has some effect on neurotransmitters. I take one Omegavia with lunch and one with dinner, since those are my larger, fattier meals. Would it be better to just take two with lunch? My insomnia has been getting worse, especially around full moon time. I am battling late stage neurological Lyme disease. Do you think I should add in some more DHA, due to my high levels of brain inflammation? Any research on this? Thanks!

              • Hi Joe – there is no clinical trial that shows Omega-3s to worsen insomnia. But, as the saying goes, you’re not a statistic. You are a person. And you may respond uniquely to environmental and dietary inputs. You are taking only 2 OmegaVia a day, which is not considered a very high dose. There is no harm at all in taking both pills with lunch. It will be well-absorbed. If you think taking the pill at night may be contributing to this, it is perfectly fine to take it earlier in the day.

                Having said that, we’re also having this discussion in May 2020, during the first big wave of Covid 19 pandemic. Virtually everyone I know is having some sleep issues due to the stress of fear, uncertainty, and reduced outdoor activity. This may be contributing to your situation. Do not discount it.

                As far as adding a little DHA for neurological support…it’s not a bad idea independent of your Lyme disease diagnosis. (Sorry to hear about that, btw.) But I have no idea if a little more DHA will help with Lyme because we have no clinical evidence.

                If brain inflammation is a focus, try to target it with dietary modifications as well – less sugar, less refined carbs, and less Omega-6 seed oils. More prebiotic-fiber-rich veggies and seafood. More here:

                Hope this helps.

  21. Hello Vin, My daughter is 8 months pregnant and on the whole eats very healthy. She is allergic to fish. A few years ago I asked you about a particular plant based omega 3 oil which you approved. It seems as if there are now many more vegetarian options. Have you noticed this?? If this is the case can you recommend a few that are more outstanding in your opinion as I don’t really know what to look for for a really great product. She struggles with mood issues from day to day (also when not pregnant) so wondering if there is one that is higher in the EPA for mood. How much EPA should she aim for? She also seems so forgetful and exhausted! I use a number of Innovix supplements and want you to know I am so pleased with their quality and thank-you very much for consistently being there for us all!!

    • Hi Elsha – oh congratulations on almost being a grandparent!

      Most people who are allergic to fish are not allergic to fish oil because there is no fish protein in the supplements, especially the highly concentrated ones. But that is a risk decision only your daughter and her OB should make. Yes, I have noticed a lot of vegan Omega-3 options out there. It is still early days with algae-derived DHA. So, none are especially outstanding.

      In the meantime Nordic Naturals is a safe bet:

      As for mood, I wrote this piece for our sister brand’s site: Hope you find it useful. Mood is a complex issue – lots of small things help, but no one supplement or pill will fix it completely. Supplements are a small part of it, so we gathered several mood supporting ingredients into a pack here: but I would not feel comfortable suggesting this to someone who is 8 months pregnant.

      Things that most pregnant women in their third trimester lack are DHA, choline, magnesium, Vitamin D3, iodine, Vitamin K2, and iron. DHA needs during the last 2 months of pregnancy is MUCH higher than what prenatal supplements provide, so you will need to take about 600 to 900 mg DHA per day. Oh, I forgot iron – about half of all pregnant women are deficient in iron. Abotu 80% are deficient in choline, which is extremely important. She should get lots of sun exposure – UV B rays shift gut microbiome to a blend that is much healthier…in addition to Vitamin D3. Sun exposure should be required during pregnancy, but we’re all focused on the negative with regards to sun and UV. More on all that here:

      Anyway, good luck and wish your daughter the best.

  22. Elsha here again. I use the Innovixlabs Triple Strength Omega 3 so do you know then if it contains fish protein? Can this be tested? If it’s generally the protein people react to and there’s no protein in the product might it contain something else they could react to when allergic to fish? Sorry for all the questions!

    • Hi Elsha – no, there is no fish protein in the InnovixLabs Triple Strength Omega-3. The gelatin capsule is made from beef. The gelatin capsule of OmegaVia products are made from fish gelatin, so OmegaVia will have fish protein…not in the oil, but in the capsule.

      Protein levels in fish oil can be tested by some labs. But no one tests it because there is no protein in purified oils…and proteins are usually considered healthy.

      If you have an allergic reaction to a highly concentrated Omega-3 supplement with a bovine gelatin capsule, then there is something in the pill other than fish protein that you are allergic to. You’d have to work with an allergist to get to the bottom of that.

  23. A few more very quick questions but first thank-you so much for the helpful information. I would never think of paying that much attention to the capsule itself. 1)How seriously do you take expiry dates? 2)How far can I go over the Innovixlabs Triple Strength Omega-3 expiry date and 3) is it best to keep them in the fridge then but not in freezer? Thank-you again!!

    • Hi Elsha – expiry dates are required by the FDA and supplement manufacturers need to have back-up/proof documentation that a product is indeed good until the expiration date. This means the product must have the amount of claimed ingredients even on the expiration date.

      However, we are not talking about milk or meats. For minerals like magnesium or calcium, expiration dates don’t mean much because the mineral content will remain the same and as long as the seal on the bottle is intact, chances are good that you can use your calcium supplements for a long time after the expiration date.

      With Omega-3 and fish oil supplements, expiration dates mean two things: level of Omega-3 decreases a tiny little bit. Example: a label that says the pill may have 900 mg of Omega-3 may only have 875 mg a year after expiration. This by itself is not a bad thing…but the thing about Omega-3s that you need to pay attention to is the rancidity. Even though softgels are protected from light, oxygen, and heat (drivers of rancidity) the oil within may gradually start to become more rancid. Not much…but it can be measured.

      With Probiotics, the issue is the number of live cultures – and these are live organisms, so they gradually die and the product may lose potency. For some probiotics, dead or alive makes no difference – even remnant genetic strands from dead probiotics can impart health benefits. But this is not the case with all probiotics, just some.

      So expiration dates mean different things to different types of nutrients.

      Personally, I would feel comfortable taking one of our expired Omega-3 products…for may be 6 months past expiration. Even though there is no harm or safety risk, my reluctance to continue taking an expired product is…why would I take old stuff if I have access to fresh stuff?

      As for storage, if I have a bottle and don’t plan on using it for a year, I will put it in the freezer. If I plan on using it within the next month or two, I’ll keep it in the fridge or freezer. Unlike you, I (obviously) don’t buy OmegaVia. I have Quality Control Dept send me bags of 1000 softgels from each batch produced, which I keep in the cheese/veggie drawer of the fridge. My family consumes 8 to 10 OmegaVia capsules a day, so 1000 pills doesn’t last long.

  24. Hello, There is a new 2020 USC study about Omega 3 and DHA

    A summary of the study: “Higher doses of omega-3 supplements may be needed in order to make a difference, because dramatic increases in blood levels of omega-3s are accompanied by far smaller increases within the brain.” Also, DHA levels need to be higher, especially if the individual has the risk-inflating APOE4 mutation.

    Some gaps and questions from the study.
    Is the study referring to One copy of ε4 variant, or Two copies of ε4 variant?
    Is it acceptable to take 2 grams DHA daily, or are there additional questions and concerns that must be considered?

    I would be interested in some thoughts and opinions.

    • Hi Gary – the study isn’t clear about the number of ApoE4 mutation.

      Free full text here:

      Taking 2 grams of DHA daily is not known to cause side effect. That’s more than the human body needs, but this dose is not known to cause issues, other than possible increase in large (‘healthy’) LDL.

      The brain (or cerebrospinal fluid) is not the place to look for EPA. That the authors sought to measure EPA there is fine. The more we know the better, but the brain and nerves are where DHA is stored. It is very interesting but we don’t know how relevant it is that EPA doesn’t increase in people with ApoE4 mutations.

      The importance of this study is that it may change our understanding of dose response. Generally, 600-700 mg DHA per day is where you begin seeing benefits, but that could be in the general population. It is possible that based on this study, cognitive research ought to use 2 grams or higher.

      It is flawed to view Alzheimer’s from an Omega-3-only perspective. This disease is often called Type 3 diabetes and may be a neural expression of metabolic disorder among people with ApoE4 issues. Any effort to reduce risk of Alzheimer’s MUST include strict dietary and lifestyle modifications, particularly elimination of sugar and refined carbohydrates, high intensity exercise, increased consumption of brain-supportive nutrients (of which DHA is one), and time-restricted feeding or intermittent fasting. Of course, there are genetic and environmental factors that contribute and all possible causes need to be addressed separately.

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