NEW! DHA 600 Omega-3 Pills

Prenatal supplement…or brain health supplement?*

Yes.

 

OmegaVia DHA supplement
The new OmegaVia DHA 600 has, well, 600 mg of DHA per pill. It’s the only
product that provides enough DHA for the second half of pregnancy.

OmegaVia DHA 600 is our newest product.

You kept bugging us. Now here it is.

What is it?

  • It’s an ultra-pure DHA-only supplement made from Anchovy, Sardine, and Mackerel
  • Each capsule has 600 mg of DHA Omega-3
  • The DHA is in the well-absorbed triglyceride (rTG) form

Who should take it:

  • Men and women considering parenthood ( 4 months before conception)*
  • Pregnant and nursing women (600 to 900 mg DHA per day)*
  • Adults concerned about brain health*
  • Adults concerned about eye health*

How much does it cost?

$25.99 for 120 softgels

Why it’s special:

  • It has the most DHA available in one pill. (Yet it’s not a horse pill)
  • It’s made using a new gentle, heat-free technology called enzymatic concentration. Less heat equals less damage to delicate Omega-3 molecules.

Features:

  • Purified to remove mercury
  • The Omega-3 is in the well-absorbed triglyceride form
  • It’s enteric coated to reduce odor and burping
  • It is third-party tested for your peace of mind
DHA supplement pill size comparison
DHA 600 is larger than EPA 500 pills but much smaller than regular OmegaVia

OmegaVia-DHA-600-Supplement-Facts-Panel

What’s the right DHA dosage for brain health?

There is always some news report about why fish oil doesn’t work.

Recently, there was a lot of media attention about one study that used 320 mg of DHA per day. The media reported that it does nothing for brain health or eyes. A ‘waste of money,’ said Newsweek.

Case closed. Toss your fish oil pills.

Not so fast.

While we were developing this formula, I spent a lot of time reviewing DHA studies (certainly more time than Jessica Firger from Newsweek) from the last decade that focused on cognitive health.

I noticed a couple of things:

  1. Studies that used less than 500 mg per day consistently failed to provide cognitive benefits.*
  2. Studies that used more than 600 mg or so showed fairly consistent benefits.*

600 to 700 mg of DHA per day seemed to be the sweet spot – the least amount of DHA that could be expected to provide benefits. It seems fair to say that if you take two pills (1200 mg DHA per day) that you’d tilt the odds in your favor.

This is the reason why our formula is ‘DHA 600’ and not ‘DHA 500.’ DHA 700 would have been better but we wanted to keep cost and pill size approachable.

This data was brilliantly reported by Adam Ismail of GOED as a response to mass media trashing DHA.

In the chart below, I have shamelessly combined my data with Adam’s eye-opening chart. (Yes, there are a couple of studies that used > 500 mg DHA that failed to provide benefits and if I keep looking, I’ll probably find a study or two that shows benefits at sub-500 mg dosage. That’s how science works.)

DHA & Brain Health Clinical Studies:
Dosage and Results

DHA dosage and cognitive benefits
Comparison of recent DHA research: studies that used less than 500 mg of DHA per day showed a near unanimous lack of cognitive or brain health benefit.

 

 

Dosage matters.

As Dr. Barry Sears regularly explains to his readers, if you take a placebo dose, you can expect a placebo result.

 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Disclaimer

This website is for your education and general health information only. The ideas, opinions and suggestions contained on this website are not to be used as a substitute for medical advice, diagnosis or treatment from your doctor for any health condition or problem. Users of this website should not rely on information provided on this website for their own health problems. Any questions regarding your own health should be addressed to your own physician. Please do not start or stop any medications without consulting with your doctor. We neither encourage you to do so, nor can we be held responsible for the fall out of failing to seek the counsel of a medical health practitioner.

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Vin Kutty
Vin Kutty, MS, is co-founder of Innovix Pharma. He is a nutritionist and Omega-3 expert with 20 years of experience.

Comments

Join the Conversation

  1. Hi,I currently the omegavia 780 epa 260 dha.In some of my reading I have seen products recomending higher levels of dha. I am wondering what your current thoughts are on this subject and could you comment on the trade marked product vesisorb.
    Thanks

    • Hi Don – think of EPA and DHA has your right hand and left. Ideally, you need both. They have different roles in the body. DHA tends to be used for structural functions like building stuff. Think bricks of a building. EPA is the water and electricity flowing thru the building. EPA plays a more functional role, not a structural one.

      EPA supports healthy inflammation response, and also support mood health and healthy triglyceride levels when used as part of healthy diet and exercise plan. DHA supports brain and eye health. It is critical during pregnancy and breast feeding due to its importance in brain development.

      OmegaVia (the original one) was designed to have a little more EPA than DHA to support healthy inflammation response. However, there is enough DHA there still to meet your daily needs. The new DHA product (above) is for those focused on pregnancy, brain and eye health.

      *Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

  2. Hi,

    I am not sure which Omegavia product I should buy. I bought the OmegaVia EPA 500. EPA Omega-3. Triglyceride-form EPA-only formula, 120 Capsules. 500 mg EPA per pill on Amazon

    And then I tried the OmegaVia Omega-3, Enteric Odorless/Burp-Free. 1105 mg Omega-3 – Highest Omega-3 per pill.

    The first one helped my mood. I was able to concentrate better.
    The second one was great for my skin and reduced my challenges with inflammation considerably. It has also assisted my recall but not my
    concentration. Not sure why that is.

    These are my challenges: inflammation, and brain health, mood, skin. I was a battered child and teen and suffered several blows to head, ages 6-19. I have been taking the fish oil along with my green foods, (spirulina, barley grass juice powder, e3live, and wheat grass juice powder). The fish oil helps me remember numbers well this is a big deal for me because I have not been able to recall numbers this well since I was thrown against a wall at the age of 8. So, I am very excited about what it is doing for my brain.

    The Omegavia is the best fish oil product I’ve come across.

    Do I need to purchase two different ones? I am running low on the product.

    Lastly, I have also started taking Viobin Wheat Germ oil. I take one teaspoon each day. Is it okay to take Wheat Germ oil even though i am taking the fish oil? I don’t mind alternating. It has been a great help. Thank you.

    • Hi WM – your post made me go quiet for a while.

      Since you want to focus on a lot of different areas, I think the original OmegaVia with 1105 mg of Omega-3 per pill will do. You don’t need to buy two separate products. I am not a big fan of greens – you’ll do better with increasing the quantity and variety of vegetables and tubers in your diet. Certainly not a big fan of wheat germ oil or anything that comes from wheat.

      Take care of yourself. Since others didn’t.

  3. Hi vin, i am currently taking blue ocean professional omega 3 2100 mg for the last one month. They didn’t mention their source of oil on label and when i inquired from them they said their source would be either Peruvian Anchovies or Alaskan Pollock. Is it good source or not, and when can we get your products in india? Am i taking right product for anti-inflamatory purpose.

    • Hi Babli – Blue Ocean is generally a good product. But one of their products failed a recent ConsumerLab.com test. It had a little less Omega-3 than claimed on the label. But the product quality is otherwise very good from my experience. If you take 2000-3000 mg of Omega-3 per day as part of a healthy diet and exercise plan, you should notice an overall healthy inflammation response.*

      *Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

  4. Hi Vin!
    I am loving Omegavia so far. I have been aware of the benefits of DHA during pregnancy throughout my pregnancy and was taking a highly recommended Fish Oil that had much higher EPA than DHA. It wasn’t until my 6th or 7th month that I found your product and began taking it and have gathered a lot more information about EPA and DHA.

    Will the benefits be lessened because I have been taking much more EPA than DHA throughout this pregnancy? And could there be negative effects?
    Should my intake of DHA be balanced by an intake of EPA? Is there a ratio amount?
    (I am currently taking the 600 capsule twice a day along with an EPA/DHA capsule EPA 625/ DHA 244.)

  5. Is there a health reason to prefer this DHA 600 to the Ovega-3 vegan DHA?

    I currently take two EPA 500 and one regular omegavia per day to help with mood. I’m thinking about pregancy and the regimen I was thinking of was 2 regular Omegavias and 2 of the vegan ovega-3 per day. Is there a reason to think that -from a nutrition perspective, not pill quantity or cost-your DHA 600 would be better than taking 2 ovega-3 pills?

    • Hi EastCoaster – no. There is no health or nutrition reason to choose Ovega-3 over this item. If you are vegan, then, yes, Ovega-3 is the obvious choice.

  6. I tried to post this earlier.

    Right now I take 2 500 EPAs and 1 regular omegavia per day (mostly for mood). I’ve been thinking about pregnancy and wondering about taking 2 regular omegavias and 2 of the ovega-3 vegan dha.

    Right now I’m getting 1780 mg EPA (500×2 + 780) and 260mg DHA plus 65m other omega 3.

    Under the proposed regimen I would get:

    EPA (780×2 + 135×2) DHA (260×2 + 270×2)

    EPA 1830mg DHA 1060mg DHA

    Is there any nutritional reason why it would be better to get the dha from fish than from the algal oil?

    Thanks

    • Hi EastCoaster – I answered your earlier question yesterday…may be you’re not seeing it for some reason.

      There is no nutritional reason to choose fish over algae. Or vice versa. If you get the DHA into your body, your body will thank you, regardless of source. Some algae extracted DHA products may have some remaining solvents like hexane, acetone, or isopropanol. I have no idea if that is the case with your algae DHA.

      • Thanks for the response. There was a delay in the post showing up, so I thought my comment hadn’t posted.

        I was also asking about the best way to go about making sure that I get adequate EPA for myself even when upping DHA.

        • Hi EastCoaster – I think one regular OmegaVia and one DHA 600 should be plenty. As you get closer to 2nd and 3rd trimesters of pregnancy, you can always increase either pill by one.

  7. You have mentioned before in one of your articles about unopposed EPA being effective when one is interested in getting its benefits. Does the same work for DHA? Should I avoid a product that has EPA if I am more interested in the DHA component?

    • Hi NG – no need to avoid either. That would be a bad idea. For mood support, the evidence shows that more EPA than DHA helps. No such evidence exists for any other health condition.*

  8. Hey there Mr Kutty,

    My plan to improve my health, the dietary portion of it, is temporarily face down in the water. I have read numerous links lately regarding statins: specifically, statins and fish oil, as well as other related pharmacological and supplemental studies including coq10, K2 and vitamin E, etc. I thought, “Alright, finally! There it is in black and white–proof that it works–empirical results.”

    However, I went on to read anther link, “Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms”. That was a veritable horror show about the apparent Ted Bundy of prescription medications. Who knew? Before you correctly suggest I see my Doctor, keep in mind that she prescribed them. On one hand, they are touted as miracles, on the other hand, not so much. Kind of like the wheat/whole grains issue—ground zero of healthy food… that is going to kill you. Have you any advice? These conundrums are frustrating. Thanks

  9. Hi Dennis – I’d go with the regular OmegaVia for now. It is the best way to get a high amount of Omega-3 into your body with one pill. I’d take 2-3 per day.

  10. Hello, Thank you for your putting so much information out there! I truly enjoy your articles and I can’t tell you how much I appreciate them! I’ve been reading your articles for a while. I am currently a little over 5 months pregnant with my first and it’s GIRL :).

    I’ve been taking the following:
    4 Nordic Naturals Prenatal (serving size: 2)- 480 DHA & 205 EPA
    1 Carlson super DHA 500
    Total: 1460 DHA and 410 EPA

    I didn’t realize that EPA was as important as DHA and I am concerned about it. From your experience with your wife, what would you recommend that I take for my last trimester. I am thinking about ordering the Omegavia regular and the Omegavia DHA 600. How many should I take Starting my 6th month and is ordering from Amazon the same as ordering directly on your website? Lastly, what magnesium pills do you recommend and how much mg should I be getting?

    Thank you in advance for your assistance.

    • Hi Aida – congratulations! And glad you find the articles here useful. I think your total DHA is fine for the whole pregnancy. EPA is OK too, but could be higher.

      You could keep your routine the same or you could use OmegaVia (regular) and OmegaVia DHA 600 in combo. One regular and 1 or 2 DHA per day.

      Buying from this site or Amazon is the same. Except I don’t think Amazon offers ‘Auto-ship’ and the discount that goes with it. As for Magnesium, try the one from our sister company, InnovixLabs on Amazon. Aim for 400 mg Magnesium per day, but check with your OB before you add anything new to your routine. Good luck with the pregnancy.

  11. Hi Vin,

    I read somewhere that your body becomes saturated with DHA at a dose of about 900 mg/day, so taking more than that won’t do any good. Is that true?

    • Hi Peter – I dont know how that could be true. It is possible that there is no need for more than 900 mg DHA per day, but it can always be converted to EPA if there is excess.

    • Hi Peter – DHA is a longer molecule than EPA. By 2 carbons. Generally, elongation of any molecule is more cumbersome and consumes energy, so the body isn’t very efficient at it. So conversion of EPA to DHA is not as efficient as the reverse. The answer to your question: yes, EPA can be converted. But DHA to EPA works much easier and faster.

  12. Hey Vin,

    (This unrelated to DHA but this was the most recent article)

    I have been following your health recommendations and would like to get your take on some things.

    I am thinking about incorporating fish into my diet certain weeks so as not to have to supplement ALL the time with EPA pills. Does mercury toxicity concern you? (I heard Salmon was good on this front)

    Per your recommendation I have been eating a lot of eggs (6 whites, 2 yolks a day) but I recently came across research connecting eggs to Prostate Cancer and its progression. Have you heard about this?

    Lastly, I recently read a few articles warning against olive and coconut oil (especially coconut). Is this just another case of people fearing any and all fat?

    http://nutritionfacts.org/2013/11/19/why-are-eggs-linked-to-cancer-progression/

    https://www.pritikin.com/your-health/healthy-living/eating-right/1103-whats-wrong-with-olive-oil.html

    • HI Sullivan – wild salmon is an excellent food. Mercury is not high in salmon.

      There has never, ever been cause and effect shown between eating eggs and cancer of any sort. I feel pretty comfortable is saying virtually everyone who has cancer has eaten eggs at some point. So it is easy to connect the two. Otherwise, I think it is hogwash. I feel the same way about the olive/coconut oil article.

  13. Hi Vin,

    What percentage of DHA is present in the sn-2 position of this product?
    And maybe, if you have the time, could you elaborate on the importance (or not) of this in your opinion?

    Thanks!

    • Hi Nik – as far as we know (based on NMR analysis), the DHA is equally distributed between sn-1, 2, and 3 positions on the glycerol backbone. In other words, about a third of it is probably in the sn-2 position.

      Just curious – why do you ask?

      • I’ve been following Jack Kruse for some time. He says that DHA has to be in the SN-2 position to get into the brain and nervous system.

        Rhonda Patrick seems to favor Krill for DHA and fish oil (she apparently uses Nordic Naturals Extra EPA) for EPA. Maybe you should sponsor her with some OmegaVia EPA? 😉 Anyway, seems like a decent approach? Given Krill is too expensive to cover all to make sense.

        Feel free to cut out parts of the text if you wish. I just appreciate your opinion since I like your writings and view on things.

  14. Hi Vin,
    I have 2 boys – a 10yr old, who has concentration issues and a 4.5 yr old with sensory issues. Their diet is full of sugar juice and artificial stuff, while I am tackling that, please advise what Omega-3 to give them ? And how much.

  15. Hello Vin,

    Earlier I used to take Nordic Naturals EPA Xtra, but I recently started using “Omegavia Fish Oil” supplement after Omegavia switched to the rTG form.
    Now, the supplement is Enteric-Coated, which means it won’t be digested in the stomach, and if I want to avoid this is it OK if I chew on the softgel? Once I feel that all the oil has been taken in, I spit out the capsule body. I have done it a couple of times and the oil tastes fine (this really shows it’s good quality stuff, so kudos to you guys!!!), can you please tell me if this method is OK and doesn’t affect the absorption in a negative way.

    • Hi Pankaj – I would not recommend chewing the capsule to release the oil in the mouth. There is no biological or scientific need to. There is almost no gastric digestion of Omega-3 in the stomach. Virtually all Omega-3 digestion happens in the intestines. So why go through the hassle? The only people up in arms about enteric coating are companies selling non-enteric-coated fish oil.

  16. Hi Vin,

    I have been diagnosed with postural orthostatic tachycardia syndrome (POTS). My doctor says that I should consume Omega-3. I know that a high EPA, lower DHA formula is beneficial for most people, but in my case would you recommend a higher amount of DHA for such a neurological condition? Right now I am consuming 1.5 grams, mostly EPA because anxiety/depression are some of my symptoms. But I am thinking now I may need to adjust it because of my recent diagnose. I have also heard Choline supplementation is beneficial for POTS. What are your thoughts? Thank you.

    • Hi Joe – I am not aware of any Omega-3 research that’s been applied directly at mitigating POTS. If your doctor wants you to take Omega-3 and you want to focus on nervous health, then a little DHA, like this DHA 600 may help. Frankly, I don’t know whether it will or not. However, here is something to keep in mind: even though there appears to be a strong genetic component here, POTS is often seen with other ‘lifestyle’ diseases like chronic fatigue, diabetes, and IBS, most of which can be somewhat managed with strict control over diet and lifestyle that reduce inflammation and enhance gut health/microbiome. Something to think about in addition to adding DHA to your EPA routine.

    • Hi JW – it’s basic high-vacuum distillation. The two molecules, EPA and DHA, have different molecular weight and boiling points. They are easily separated.

  17. In another article on this website: https://omegavia.com/why-omegavia-is-high-in-epa-omega-3-dha-and-your-brain/ it says that the brain only takes in 4 mg of DHA per day, and that the half life is around 2.5 years. I thought that this meant higher dosed DHA is not necessary for maximal brain utilization daily?

    The article says that the heart, eyes, and other cells also use DHA, but it seemed the “gist” was that higher DHA isn’t necessary and it could inhibit DGLA production since DHA competes with GLA for an enzyme called delta-6-desaturase which means less GLA production.

    Could you clarify more into what an optimal dosage of DHA would be for someone interested in brain performance. I wonder if the 4 mg rate limit be increased?

    • Hi Eli – that article was written with a narrow focus and with data that now feels irrelevant. I still think the 4 mg per day number is still correct, but it does not take into consideration other benefits or mechanisms of action of DHA. There appear to be unique benefits to both EPA and DHA. Example: more EPA helps with mood while more DHA helps with heart rate moderation and cognitive health. Also, it is clear that cognitive health benefits of DHA starts at around 600-800 mg of DHA per day, which is FAR higher than 4 mg. So, if you want brain performance, I’d target 600-800 mg DHA per day along with elimination of sugar, processed foods, daily exercise, plenty of prebiotic fiber, healthy sleep habits etc.

      • Thank you for the reply, I appreciate it!
        Last question I promise –

        Does EPA compete with DHA in any way when trying to cross the blood brain barrier or in the brain itself during membrane integration?

        I only ask because I see a lot of fish oils on the market with much higher EPA and although it is still easy to reach 600 – 800 mg DHA with those ratios, I wonder if much higher levels of EPA going along with it might compete/block DHA in some way.

        • Hi Eli – there is virtually no EPA in the brain. But EPA, DPA, and DHA can and do cross the blood brain barrier. But the structural Omega-3 in the brain is DHA and its incorporation into the brain is unimpeded by EPA or DPA. In other words, if you take a product with high levels of EPA (like OmegaVia), the DHA present will still be properly used by the body. It is for those seeking specific ratios that we introduced this DHA item and the EPA 500.

      • Hi,

        First of all, thanks for all the articles and replies to questions on them. All the information has been great.

        Regarding the older article (https://omegavia.com/why-omegavia-is-high-in-epa-omega-3-dha-and-your-brain/), are you able to go back and add a note at the top to see the new info in this one?

        I’m asking because the other article is still a high Google result, so I landed on it from there and didn’t see this post until browsing the site much later.

        Thanks!

  18. I found your website two years ago, when i had chronic knee pain due to a bike accident. We exchanged some messages, and i followed your advice and took 1200 EPA/day and while it didnt completely erase my pain, it reduced my pain/inflammation significantly. It was a life saver seriously.

    I learnt a lot from your advices in the comment sections, and im really thankful of this. Since that time Im telling people who has pain to try/come here to learn with omegavia and/or about high quality fish oil.

    Now I just came back again to your site to ask your advice. I just learnt recently i have/had a chronic inflammation in one of my teeth roots, and dentists were telling me it may affect all my recovery/physio/knee pain as well. So last week I had a tooth extraction, and since that time i have pain/inflammation in my mouth now. The dentists told me to take antibiotic, but if there is any way im trying to avoid antibiotics. (I have some digestion issues: too much intestinal gas and eructation and Im trying to save my stomach from further troubles) So, now im suffering (no painkillers) and looking for urgent alternative ways to reduce inflammation/pain and help my body to recover.

    Do you think higher intake of EPA daily can help in this issue? Im planning 1000-1300 mg EPA first, if there is no effect up to 2000mg EPA/day for a 10 days period of time.

    Do you may have any other advice which could help? If you say, follow the dentist order and there is no other way then take antibiotic i will accept it.

    Thanks for your advice, and sorry for my english mistakes,

    Robbie

    • Hi Robbie – I’m glad EPA helped with the knee issues. However, EPA will not replace the need for antibiotics or painkillers after tooth extraction. Antibiotics are a necessary evil and if you need it, you need to take it. For the immediate future, following your doctor’s advice is critical.

      Beyond that, if you want to maintain good dental health, start with elimination of all sweet beverages, sugar and refined grains. Floss your teeth at least once a day. And take Vitamin K2 to strengthen your teeth. Our sister company makes a good K2: https://shop.innovixlabs.com/products/full-spectrum-vitamin-k2

      • Thank you for your quick reply! Ok, I will wait one more day, and if its not going to get better, i will choose antibiotics.. (Im doing this in the last 6 days, waiting for some miracle to happen, but nothing happened yet just the pain stayed..) Do you may have any research/learning materials about the health benefits of K2 ? I never heard of K2 before, and tonight im going to examine this topic. Do you may know any natural food supplement as teeth pain killer?

        Thanks for your quick response, please let me know if you anytime end up in Budapest:)

        Robbie

  19. I was going through your site and I understand you are an authority on subject of Omega 3s. Compliment you for the wealth of information shared on on the website.

    I am writing to you with a very specific query and hope you will be able to help me.

    Background:
    I am Male, 41 years.
    Have high triglycerides (300 – 340 mg/dL) since I was 25 years & this is heriditary (runs in family with mother and younger brother also has high triglycerides).
    I also suffer from depression, which could be part attributed to fact that I am Beta Thal minor and as such my Hb levels are 11-12.

    For Triglycerides I inititally tried EPA+ DHA but it made me sleepy, drowsy, confused, lethargic & sloppy.
    Have tried multiple formulations of EPA and they all make me worse with above mentioned symptoms and makes my depression worse.
    Is this a known side effect of EPA? I read somewhere that EPA reduces cortisol in the body and dont know if that is a plausible explanation. Is it correct that EPA reduces cortisol?
    Though your website mentions EPA as main product for TGL reduction but I am apprehensive of using it owing to existing high TGL levels.

    I have tried DHA in past and it has yielded good results especially on mental performance. Have now got a bottle of Omegavia DHA 600.
    Had questions with respect to Omegavia DHA 600:
    1. Understand DHA in OmegaVia 600 is in Triglyceride form.
    Given my existing condition of High triglycerides, would OmegaVia 600 help in decreasing TGL levels or TGL form of DHA may actually elevate existing TGL levels?
    2. If yes to above question, what should be dosage & duration of DHA to see results.
    3. Can DHA also help with depression? My depression is more due to dopamine deficiency/neurotransmission.
    4. Does DHA affect cortisol levels as well ?

    I eagerly look forward to hearing your comments.
    Also, please do let me know any suggestions or advice you may like to give based on my condition and how Omega 3s could help me.

    Regards,

    Ron

    • Hi Ron – EPA and DHA are not known to cause sleepiness or confusion. Neither are these two Omega-3s known to worsen depression.

      As for cortisol, topical application of cortisol temporarily weakens the effect of Omega-3.

      EPA alone is not suggested for triglyceride reduction. We recommend a combination of three things:
      1. A diet that is very low in sugar, grains, and refined carbohydrates. In other words, mostly vegetables, and some protein, with generous amounts of healthy fats.
      2. An exercise plan that includes both resistance and aerobic exercises
      3. 3000 mg of Omega-3 per day (both EPA and DHA)

      The DHA in DHA 600 will not elevate triglyceride because of the triglyceride form DHA – those are two different things.

      EPA seems to help with mood more than DHA.

    • Hi Kal – there are many reasons why studies do or do not show benefits. This applies to all nutrition science, not just Omega-3.

      I’m attaching our standard response regarding this study.

      First, there were two studies published at the same time. One was mildly positive and the other was ‘null’ or no benefit. The positive study was completely ignored by the media. https://www.ncbi.nlm.nih.gov/pubmed/30019767

      1) There are decades of research showing a cardioprotective effect of omega-3s. This includes meta-analyses, RCTs, epidemiological studies, animal studies and in vitro studies.

      2) While Dr. Lee Hooper, the project lead for this systematic review, says she is “… confident in the findings of this review which go against the popular belief that long-chain omega-3 supplements protect the heart,” her analysis focuses on only part of the existing evidence and even there contradicts previous meta-analyses that focused more carefully on some of the most relevant outcomes (cardiac death, blood pressure, triglycerides). What she gained in comprehensiveness, she lost in depth.

      3) Perhaps the biggest shortcoming of the CHD meta-analysis is that it is underpowered. Most readers of this article will assume that if there is a true effect on CHD mortality, for example, then this study would have a good chance of detecting it. In fact, that is not the case – a real effect of this size would be unlikely to be detected unless the number of participants were doubled. This stresses the importance of considering all existing science, not just RCTs.

      The way the authors define cardiovascular mortality is non-standard, and using this definition reduced the number of events considered, as compared to other published meta-analyses. This choice artificially reduced the chances of an already underpowered analysis to detect a significant effect.

      And finally, here is a related piece I wrote back in 2014: https://omegavia.com/why-fish-oil-doesnt-work/

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